Peyronie’s Disease and Smoking: Unravelling the Connection

HomeLifestyleHealthPeyronie's Disease and Smoking: Unravelling the Connection

Peyronie’s disease or PD is characterized by penile curvature and the pain during erection and sexual activity causing unrelenting anguish. Many men have slightly bent penis, but it can’t be characterized as PD. When the significant curvature of penis starts to generate pain during erection and sexual activity, only then it can be identified as PD. PD is believed to have a wide range of causes but exactly what causes PD in a man is not known yet. While the exact cause of Peyronie’s disease remains elusive, research has shed light on the potential concatenations between this condition and smoking. In this article, we will explore the connection between Peyronie’s disease and smoking, examining the impact of smoking on the development, progression, and severity of this condition.

What is Peyronie’s Disease

Peyronie’s disease is named after François de la Peyronie, a French physician who originally characterized the ailment in 1743. It typically manifests as the formation of scar tissue, or plaques, in the tunica albuginea, the fibrous sheath surrounding the erectile chambers of the penis. As these plaques develop and progress, they can cause the penis to bend or curve during erections, leading to pain, difficulty with penetration, and psychological distress. 

Symptoms and Causes of PD

A bend or curvature in the penis during an erection is one of the most common Peyronie’s disease symptoms in men, however they might differ from person to person. This curvature can range from slight to severe, and it may cause pain or discomfort during sexual activity. Peyronie’s disease can also cause a shortening of the penis or a constriction of the urethra, making urination difficult. Other symptoms include penile lumps or bumps, loss of feeling or numbness and a decline in erectile function.

The exact aetiology of PD for men is unknown, however it is thought to be the result of repetitive penile damage. This injury can develop during sexual activity or as a consequence of other damage to the penis, such as a sports injury or an accident. Other risk factors for the progression PD in males include age, smoking, diabetes, high blood pressure, and a family history of the disorder. Moreover, antidepressants and beta blockers are two medications that may increase the likelihood of developing Peyronie’s disease.

Social stigma and psychological impact

Peyronie’s Disease can be a difficult condition for men to cope with, both physically and emotionally. The curvature and pain associated with the condition can make sexual intercourse difficult or impossible, which can lead to feelings of frustration, embarrassment, and shame. Men with PD may also worry about how their condition will be perceived by sexual partners and may be reluctant to seek medical treatment for fear of being judged or stigmatized.

Historically, there has been a great deal of social stigma associated with Peyronie’s Disease and other conditions that affect male sexual function. Men with erectile dysfunction, premature ejaculation, or other sexual problems have often been seen as weak or inadequate and have been reluctant to seek help as a result. However, in recent years, there has been a rising acknowledgement of the psychological impact that Peyronie’s Disease and other sexual issues may have on men, as well as a growing awareness of the need for compassionate and effective medical treatment.

The Link between Peyronie’s Disease and Smoking

Research has uncovered a significant association between Peyronie’s disease and smoking, suggesting that smoking can contribute to the development and progression of this condition. Several factors contribute to this connection:

Vascular Damage: Smoking is known to damage blood vessels throughout the body, including those supplying the penile tissues. This vascular damage reduces blood flow and compromises tissue oxygenation and nutrient delivery, which can impede the body’s natural healing processes and contribute to the formation of fibrous plaques.

Inflammation and Fibrosis: Smoking triggers a systemic inflammatory response in the body, which can lead to tissue fibrosis. In Peyronie’s disease, this fibrotic process contributes to the formation of plaques and subsequent penile curvature.

Impaired Healing: Smoking hampers the body’s ability to heal and regenerate tissues. It disrupts collagen synthesis and remodelling, inhibits the production of growth factors necessary for tissue repair, and compromises the immune response. These factors can all contribute to the formation and progression of Peyronie’s plaques.

Research Findings and Statistics

Numerous investigations on the relationship between Peyronie’s disease and smoking have repeatedly shown the negative influence of smoking on this illness. A research paper published in The Journal of Sexual Medicine, for example, discovered that smokers had a considerably greater chance of getting Peyronie’s disease than nonsmokers. The study also discovered that the chance of acquiring Peyronie’s disease rose with the amounts of cigarettes smoked each day. Another study published in The Journal of Urology discovered that smoking was linked to a higher severity of Peyronie’s disease, which resulted in more substantial penile curvature and functional impairment.

The Importance of Smoking Cessation

Quitting smoking is critical for people with Peyronie’s disease to properly manage the illness and enhance their overall sexual health. Quitting smoking can help people avoid additional disease development, decrease inflammation and fibrosis, and perhaps improve their responsiveness to therapy. Beyond Peyronie’s disease, smoking cessation has broader advantages for sexual health. Quitting smoking can assist improve erectile function and overall sexual pleasure. Smoking is a known risk factor for Erectile Dysfunction (ED) and other sexual dysfunctions.

Smoking Cessation Strategies

Quitting smoking can be challenging, but numerous resources and strategies are available to support individuals in their journey towards smoking cessation. These include:

Medications: Various medications, such as nicotine replacement therapy (NRT) or prescription medications like varenicline or bupropion, can aid in smoking cessation by reducing cravings and withdrawal symptoms.

Behavioural Support: Counselling, support groups, or behavioural therapy can provide guidance, motivation, and strategies to overcome smoking addiction. These resources help individuals develop coping mechanisms and address the psychological aspects of smoking cessation.

Lifestyle Modifications: Adopting a healthy lifestyle, including regular exercise, stress management techniques, and a balanced diet, can support smoking cessation efforts and promote overall well-being.

History of Peyronie’s Disease Treatments

Despite the early recognition of Peyronie’s disease, it was not until the 20th century that significant advances were made in the understanding and treatment of the condition. In the early 1900s, several theories were proposed to explain what causes PD in a man, including trauma, infection, and inflammation. However, it was not until the 1950s that a more detailed understanding of the condition emerged, with the discovery that Peyronie’s disease is caused by the buildup of fibrous tissue in the penis. Since then, a variety of treatments have been developed for Peyronie’s disease, including surgery, medications, and mechanical devices. Surgery remains the most effective treatment option for severe cases of the condition, although it is associated with a range of risks and complications. Medications such as collagenase have also been shown to be effective in some cases, while mechanical devices such as vacuum pumps and penile extenders may be useful for milder cases of the condition. Modern non-invasive treatments are also gaining a lot of popularity in recent times. While several treatment options are available, more research is needed to fully understand the underlying causes of the condition and to develop more effective treatments.

Modern Treatment Approaches

One of the most commonly prescribed medications as Peyronie’s disease treatments is a class of drugs called collagenase inhibitors, which work by breaking down the fibrous scar tissue that causes the plaque buildup. Other oral therapies for Peyronie’s disease, such as oral pentoxifylline and potassium aminobenzoate, may also be used to improve blood flow to the penis and reduce inflammation. In recent years, there has been growing interest in the use of non-surgical treatments for Peyronie’s disease, such as shockwave therapy and EMTT therapy. Shockwave therapy for Peyronie’s disease involves the use of high-frequency sound waves to break down the plaque buildup, while EMTT therapy involves the use of electro-magnetic energy to dissolve the plaque. While these treatments are still considered relatively new, they show promise as potential alternatives to surgery. According to Shockwave Clinics Ltd, which is a men’s health clinic situated in UK, shockwave therapy is possibly the best non-invasive treatment a man can get for PD. MansMatters also offers other non-invasive treatments for PD such as, Tesla Chair and NanoVi Exo.


So, what have we learnt so far? We have learnt that Peyronie’s disease can be a very painful condition to experience, and smoking may have a role in the progression of this disease. Smoking may not directly cause PD but it can definitely worsen the symptoms caused by ED. So, quitting smoking is essential for a PD sufferer. It’s not an easy task though. It takes a lot of mental strength and motivation in order to quit smoking. But with proper strategies and strong willpower, it’s very much possible to do so. When it comes to the Peyronie’s disease treatments, thankfully there are a lot of options. But often times, it requires a multidisciplinary approach to effectively treat this issue. Nevertheless, with proper treatments and guidance it’s possible to get rid of Peyronie’s disease and start to enjoy the sex life yet again.


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